2-(Anilino)imidazolines and 2-(benzyl)imidazoline derivatives as h5-HT1D serotonin receptor ligands.

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Prisinzano T, Dukat M, Law H, Slassi A, MacLean N, DeLannoy I, Glennon RA

2-(Anilino)imidazolines and 2-(benzyl)imidazoline derivatives as h5-HT1D serotonin receptor ligands.

Bioorg Med Chem Lett. 2004 Sep 20;14(18):4697-9.

PubMed ID

15324890 [ View in PubMed

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Abstract

2-(Anilino)imidazolines were identified as novel human 5-HT(1D) receptor ligands, but offered no particular advantage over previously reported 2-(benzyl)imidazolines. Pharmacokinetic and functional data were obtained for selected 2-(benzyl)imidazoline derivatives.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Xylometazoline	Alpha-1A adrenergic receptor	Ki (nM)	91	N/A	N/A	Details