Effects of cyproheptadine and pizotifen on central muscarinic receptors.

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Richards MH

Effects of cyproheptadine and pizotifen on central muscarinic receptors.

Eur J Pharmacol. 1991 Apr 3;195(3):403-5.

PubMed ID

1868883 [ View in PubMed

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Abstract

The affinities of cyproheptadine, pizotifen and (+/-)-quinuclidinyl xanthane-9-carboxylate hemioxylate (QNX) were determined at muscarinic autoreceptors and postsynaptic (IP1 formation) receptors in rat hippocampal slices. The affinity values for QNX were 8.2 and 8.5 respectively. Cyproheptadine and pizotifen were less potent than QNX. Pizotifen was slightly (2-fold) less active at antagonizing IP1 formation than blocking the autoreceptors whereas cyproheptadine was equally active at antagonizing the two hippocampal muscarinic receptors.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Pizotifen	Muscarinic acetylcholine receptor M2	Protein	Humans	Unknown	Antagonist	Details