An adverse interaction between warfarin and 5-fluorouracil: A case report and review of the literature.

Article Details

Citation

Copy to clipboard

Brown MC

An adverse interaction between warfarin and 5-fluorouracil: A case report and review of the literature.

Chemotherapy. 1999 Sep-Oct;45(5):392-5. doi: 10.1159/000007230.

PubMed ID

10473927 [ View in PubMed

]

Abstract

Adverse interactions between warfarin and 5-fluorouracil (5-FU) have been reported. Such an interaction occurred in a patient with lung cancer receiving vinblastine and 5-FU. This case is the first involving a patient taking minidose warfarin for prophylaxis of catheter-associated thrombosis. Although the mechanism of the interaction is unclear, it has been postulated that 5-FU interferes with the synthesis of hepatic cytochrome P-450 2C9. Because warfarin and 5-FU are regularly coadministered, this adverse interaction might be occurring more frequently than is realized. Clinicians should be aware of this interaction and should regularly monitor the prothrombin time of patients receiving warfarin and 5-FU.

DrugBank Data that Cites this Article

Drug Enzymes

Drug	Enzyme	Kind	Organism	Pharmacological Action	Actions
Floxuridine	Cytochrome P450 2C9	Protein	Humans	Unknown	Inhibitor	Details
Fluorouracil	Cytochrome P450 2C9	Protein	Humans	Unknown	Inhibitor	Details