Beta-blockers and glucose control.

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Mills GA, Horn JR

Beta-blockers and glucose control.

Drug Intell Clin Pharm. 1985 Apr;19(4):246-51.

PubMed ID

2861072 [ View in PubMed

]

Abstract

Literature on the effects of beta-blockers on blood glucose is reviewed. Data are presented regarding the adrenergic influences on glucose regulation and the effects of beta-blockade during hypo- and hyperglycemia in normal and diabetic individuals. beta-adrenergic stimulation enhances insulin and glucagon secretion, as well as glycogenolysis, gluconeogenesis, and lipolysis. alpha-adrenergic stimulation inhibits insulin secretion and may inhibit glucagon secretion and enhance liver glycogenolysis. In nondiabetics, beta-blockers represent minimal risk of affecting glucose control. In insulin-dependent diabetics, beta-blockers can prolong, enhance, or alter the symptoms of hypoglycemia, while hyperglycemia appears to be the major risk in noninsulin-dependent diabetics. beta-blockers can potentially increase blood glucose concentrations and antagonize the action of oral hypoglycemic drugs.

DrugBank Data that Cites this Article

Drugs

Sotalol

Drug Interactions

• Approved
• Vet approved
• Nutraceutical
• Illicit
• Withdrawn
• Investigational
• Experimental
• All Drugs

Drugs	Interaction
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Acarbose Sotalol	The risk or severity of hypoglycemia can be increased when Sotalol is combined with Acarbose.
Acetohexamide Sotalol	The risk or severity of hypoglycemia can be increased when Sotalol is combined with Acetohexamide.
Albiglutide Sotalol	The risk or severity of hypoglycemia can be increased when Sotalol is combined with Albiglutide.
Alogliptin Sotalol	The risk or severity of hypoglycemia can be increased when Sotalol is combined with Alogliptin.
Bexagliflozin Sotalol	The risk or severity of hypoglycemia can be increased when Sotalol is combined with Bexagliflozin.