Seletracetam (UCB 44212).

Article Details

Citation

Copy to clipboard

Bennett B, Matagne A, Michel P, Leonard M, Cornet M, Meeus MA, Toublanc N

Seletracetam (UCB 44212).

Neurotherapeutics. 2007 Jan;4(1):117-22.

PubMed ID

17199025 [ View in PubMed

]

Abstract

Better pharmacotherapies for epilepsy are needed for patients who are refractory to or have tolerability difficulties with current treatments. Seletracetam, a new drug in epilepsy development, is a pyrrolidone derivative structurally related to levetiracetam (trade name Keppra). It was discovered because of its high binding affinity to the synaptic vesicle 2A (SV2A) protein, which is now known to be the binding site for this family of compounds. Seletracetam shows very potent seizure suppression in models of acquired or genetic epilepsy, as well as high CNS tolerability in various animal models. Pharmacokinetic studies in animals suggest that seletracetam is rapidly and highly absorbed, with linear and time-independent pharmacokinetics. Seletracetam appears neither to inhibit nor to induce the major human drug metabolizing enzymes, and it demonstrates low plasma protein binding (<10%), which suggests a low potential for drug-drug interactions. Initial studies in humans demonstrated first-order monocompartmental kinetics with a half-life of 8 h and an oral bioavailability of >90%. Studies in healthy volunteers showed that the treatment emergent adverse events were of mild to moderate severity, were mostly of CNS origin and were resolved within 24 h. Altogether, these results suggest that seletracetam represents a promising new antiepileptic drug candidate, one that demonstrates a potent, broad spectrum of seizure protection and a high CNS tolerability in animal models, with initial clinical findings suggestive of straightforward pharmacokinetics and good tolerability.

DrugBank Data that Cites this Article

Drugs

Seletracetam

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Seletracetam	Synaptic vesicle glycoprotein 2A	Protein	Humans	Yes	Modulator	Details