Adenosine A1 receptors determine effects of caffeine on total fluid intake but not caffeine appetite.

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Rieg T, Schnermann J, Vallon V

Adenosine A1 receptors determine effects of caffeine on total fluid intake but not caffeine appetite.

Eur J Pharmacol. 2007 Jan 26;555(2-3):174-7. Epub 2006 Oct 25.

PubMed ID

17126319 [ View in PubMed

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Abstract

Adenosine A1 receptor wild-type (+/+) and knockout (-/-) mice were used to elucidate the role of adenosine A1 receptors in caffeine self-administration in a two-bottle choice test and in the effect of caffeine on total fluid intake and plasma renin concentration. With access to water only, adenosine A1 receptor -/- mice showed greater basal fluid intake and greater plasma renin concentration than +/+ mice. Free access to both water and a caffeinated solution (30 mg/100 ml) for 14 days increased total fluid intake only in adenosine A1 receptor +/+ mice (by 23+/-3%), and both total fluid intake and plasma renin concentration were no longer different between genotypes. Mean intake of water and caffeinated solution was not different between adenosine A1 receptor +/+ and -/- mice. These data reveal that adenosine A1 receptors do not contribute to caffeine consumption, but determine the effects of caffeine on fluid intake and plasma renin concentration.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Caffeine	Adenosine receptor A1	Protein	Humans	Yes	Antagonist	Details
Theobromine	Adenosine receptor A1	Protein	Humans	Yes	Antagonist	Details