Identification of a family of muscarinic acetylcholine receptor genes.
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Bonner TI, Buckley NJ, Young AC, Brann MR
Identification of a family of muscarinic acetylcholine receptor genes.
Science. 1987 Jul 31;237(4814):527-32.
- PubMed ID
- 3037705 [ View in PubMed]
- Abstract
Complementary DNAs for three different muscarinic acetylcholine receptors were isolated from a rat cerebral cortex library, and the cloned receptors were expressed in mammalian cells. Analysis of human and rat genomic clones indicates that there are at least four functional muscarinic receptor genes and that these genes lack introns in the coding sequence. This gene family provides a new basis for evaluating the diversity of muscarinic mechanisms in the nervous system.