Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors.

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Citation

Lindemann L, Ebeling M, Kratochwil NA, Bunzow JR, Grandy DK, Hoener MC

Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors.

Genomics. 2005 Mar;85(3):372-85.

PubMed ID
15718104 [ View in PubMed
]
Abstract

Trace amines are endogenous compounds structurally related to classical biogenic amines that have been studied for decades, triggered by their link to psychiatric conditions of high epidemiological and economical relevance. The understanding of their pharmacology on the molecular level was hampered until the recent discovery of trace-amine-specific receptors. We completed the identification of all members of this novel GPCR family in human, chimpanzee, rat, and mouse and observed remarkable interspecies differences, even between human and chimpanzee. The analysis of the chromosomal localizations, phylogenetic relationships, and ligand pocket vectors reveals three distinct receptor subfamilies. As most of these receptors do not respond to trace amines, each subfamily will presumably have a distinct pharmacological profile, which remains to be identified. We propose a uniform nomenclature describing this novel GPCR family in all mammalian species as trace-amine-associated receptors (TAARs), which resolves the ambiguities and contradictions of the previous naming.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Trace amine-associated receptor 1Q96RJ0Details