Determination of biological activity of adinazolam and its metabolites.

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Citation

Sethy VH, Collins RJ, Daniels EG

Determination of biological activity of adinazolam and its metabolites.

J Pharm Pharmacol. 1984 Aug;36(8):546-8.

PubMed ID
6148400 [ View in PubMed
]
Abstract

Adinazolam and its metabolites inhibit [3H]flunitrazepam binding in-vitro. The binding affinities of these compounds is significantly enhanced in the presence of 10-5 M muscimol, indicating that both adinazolam and its metabolites are benzodiazepine agonists. In-vivo metabolism of adinazolam results in the formation of active metabolites.

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