Discovery of A-770041, a src-family selective orally active lck inhibitor that prevents organ allograft rejection.
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Burchat A, Borhani DW, Calderwood DJ, Hirst GC, Li B, Stachlewitz RF
Discovery of A-770041, a src-family selective orally active lck inhibitor that prevents organ allograft rejection.
Bioorg Med Chem Lett. 2006 Jan 1;16(1):118-22. Epub 2005 Oct 10.
- PubMed ID
- 16216497 [ View in PubMed]
- Abstract
We describe the identification, SAR, and pharmacology of the src-family selective lck inhibitor A-770041 that prolongs the survival of major histocompatibility mismatched allografts in models of solid organ transplant rejection for greater than 65 days.