NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial

BE0000027ProteinHumansNDUFV3

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. It is acted on by 2 drugs in DrugBank.

Gene name
NDUFV3
UniProtKB entry
P56181Swiss-Prot
Cellular location
Mitochondrion inner membrane
Residues / weight
108 residues · 11,940 Da
Also known as
CI-9kD · Complex I-9kD · NADH-ubiquinone oxidoreductase 9 kDa subunit · Renal carcinoma antigen NY-REN-4

Resolves to

Protein
UniProtP56181UniProt nameNDUV3_HUMAN
Gene
HGNCHGNC:7719NCBI Gene4731GenBank6002197GeneCardsNDUFV3
Pharmacology
KEGGhsa:4731
Structure
PDB5XTBPDB5XTDPDB5XTH
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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16+ReferencesStructured and connected to the statements they support
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Which approved drugs act on NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial, how selective are they, and which programs against it are still in active trials?

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