Phenylalanine--tRNA ligase, mitochondrial

BE0000028ProteinHumansFARS2

Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation. It is acted on by 1 drug in DrugBank.

Gene name
FARS2
UniProtKB entry
O95363Swiss-Prot
Cellular location
Mitochondrion matrix
Residues / weight
451 residues · 52,356 Da
Also known as
6.1.1.20 · FARS1 · Phenylalanyl-tRNA synthetase · PheRS

Resolves to

Protein
UniProtO95363UniProt nameSYFM_HUMAN
Gene
HGNCHGNC:21062NCBI Gene10667GenBank3983103GeneCardsFARS2
Pharmacology
KEGGhsa:10667
Structure
PDB3CMQPDB3HFVPDB3TEG
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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12+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Phenylalanine--tRNA ligase, mitochondrial, how selective are they, and which programs against it are still in active trials?

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