7-dehydrocholesterol reductase

BE0000031ProteinHumansDHCR7

Oxidoreductase that catalyzes the last step of the cholesterol synthesis pathway, which transforms cholesta-5,7-dien-3beta-ol (7-dehydrocholesterol,7-DHC) into cholesterol by reducing the C7-C8 double bond of its sterol core (PubMed:25637936, PubMed:38297129, PubMed:38297130, PubMed:9465114, PubMed:9634533). It is acted on by 2 drugs in DrugBank.

Gene name
DHCR7
UniProtKB entry
Q9UBM7Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
475 residues · 54,489 Da
Also known as
1.3.1.21 · 7-DHC reductase · D7SR · Delta7-sterol reductase · Sterol Delta(7)-reductase

Resolves to

Protein
UniProtQ9UBM7UniProt nameDHCR7_HUMAN
Gene
HGNCHGNC:2860NCBI Gene1717GenBank4191398GeneCardsDHCR7
Pharmacology
KEGGhsa:1717
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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7GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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28+ReferencesStructured and connected to the statements they support
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Which approved drugs act on 7-dehydrocholesterol reductase, how selective are they, and which programs against it are still in active trials?

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