Dehydrogenase/reductase SDR family member 4

BE0000032ProteinHumansDHRS4

NADPH-dependent oxidoreductase which catalyzes the reduction of a variety of compounds bearing carbonyl groups including ketosteroids, alpha-dicarbonyl compounds, aldehydes, aromatic ketones and quinones (PubMed:18571493, PubMed:19056333). It is acted on by 1 drug in DrugBank.

Gene name
DHRS4
UniProtKB entry
Q9BTZ2Swiss-Prot
Cellular location
Peroxisome
Residues / weight
278 residues · 29,537 Da
Also known as
1.1.1.184 · CR · humNRDR · NADPH-dependent carbonyl reductase · NADPH-dependent retinol dehydrogenase/reductase

Resolves to

Protein
UniProtQ9BTZ2UniProt nameDHRS4_HUMAN
Gene
HGNCHGNC:16985NCBI Gene10901GenBank4105190GeneCardsDHRS4
Pharmacology
KEGGhsa:10901
Structure
PDB3O4R
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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12GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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14+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Dehydrogenase/reductase SDR family member 4, how selective are they, and which programs against it are still in active trials?

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