Lipoyl amidotransferase LIPT1, mitochondrial

BE0000040ProteinHumansLIPT1

Lipoyl amidotransferase that catalyzes the transfer of lipoyl moieties from lipoyl-protein H of the glycine cleavage system (lipoyl-GCSH) to E2 subunits of the pyruvate dehydrogenase complex (PDCE2) (PubMed:29987032). It is acted on by 1 drug in DrugBank.

Gene name
LIPT1
UniProtKB entry
Q9Y234Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
373 residues · 42,479 Da
Also known as
2.3.1.200 · Lipoate biosynthesis protein · Lipoate-protein ligase · Lipoyl ligase · Lipoyltransferase 1

Resolves to

Protein
UniProtQ9Y234UniProt nameLIPT_HUMAN
Gene
HGNCHGNC:29569NCBI Gene51601GenBank4586380GeneCardsLIPT1
Pharmacology
KEGGhsa:51601
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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10+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Lipoyl amidotransferase LIPT1, mitochondrial, how selective are they, and which programs against it are still in active trials?

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