Pyridoxal kinase

BE0000042ProteinHumansPDXK

Catalyzes the phosphorylation of the dietary vitamin B6 vitamers pyridoxal (PL), pyridoxine (PN) and pyridoxamine (PM) to form pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), respectively (Probable) (PubMed:10987144, PubMed:17766369, PubMed:19351586, PubMed:31187503, PubMed:9099727). It is acted on by 7 drugs in DrugBank.

Gene name
PDXK
UniProtKB entry
O00764Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
312 residues · 35,102 Da
Also known as
2.7.1.35 · C21orf124 · C21orf97 · PKH · PNK

Resolves to

Protein
UniProtO00764UniProt namePDXK_HUMAN
Gene
HGNCHGNC:8819NCBI Gene8566GenBank1946349GeneCardsPDXK
Pharmacology
KEGGhsa:8566
Structure
PDB2AJPPDB2F7KPDB2YXT
Drugs

What you can answer from here — as of September 07, 2019

7DrugsApproved to experimental, with action, bond type and pharmacological action
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14GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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23+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Pyridoxal kinase, how selective are they, and which programs against it are still in active trials?

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