Pyruvate kinase PKLR

BE0000046ProteinHumansPKLR

Pyruvate kinase that catalyzes the conversion of phosphoenolpyruvate to pyruvate with the synthesis of ATP, and which plays a key role in glycolysis (PubMed:11960989). It is acted on by 7 drugs in DrugBank.

Gene name
PKLR
UniProtKB entry
P30613Swiss-Prot
Residues / weight
574 residues · 61,830 Da
Also known as
2.7.1.40 · PK1 · PKL · Pyruvate kinase 1 · Pyruvate kinase isozymes L/R

Resolves to

Protein
UniProtP30613UniProt nameKPYR_HUMAN
Gene
HGNCHGNC:9020NCBI Gene5313GenBank3327365GeneCardsPKLR
Pharmacology
IUPHAR/GtoPdb3007KEGGhsa:5313
Structure
PDB2VGBPDB2VGFPDB2VGG
Drugs

What you can answer from here — as of September 07, 2019

7DrugsApproved to experimental, with action, bond type and pharmacological action
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12GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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46+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Pyruvate kinase PKLR, how selective are they, and which programs against it are still in active trials?

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