3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1

BE0000051ProteinHumansHSD3B1

A bifunctional enzyme responsible for the oxidation and isomerization of 3beta-hydroxy-Delta(5)-steroid precursors to 3-oxo-Delta(4)-steroids, an essential step in steroid hormone biosynthesis. It is acted on by 15 drugs in DrugBank.

Gene name
HSD3B1
UniProtKB entry
P14060Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
373 residues · 42,251 Da
Also known as
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I · 3-beta-HSD I · 3-beta-hydroxy-5-ene steroid dehydrogenase · 3-beta-hydroxy-Delta(5)-steroid dehydrogenase · 3-beta-hydroxysteroid 3-dehydrogenase

Resolves to

Protein
UniProtP14060UniProt name3BHS1_HUMAN
Gene
HGNCHGNC:5217NCBI Gene3283GenBank306889GeneCardsHSD3B1
Pharmacology
KEGGhsa:3283
Drugs

What you can answer from here — as of September 07, 2019

15DrugsApproved to experimental, with action, bond type and pharmacological action
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2Metabolic reactionsDrug transformations it catalyses, substrate to product
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10GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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33+ReferencesStructured and connected to the statements they support
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Which approved drugs act on 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1, how selective are they, and which programs against it are still in active trials?

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