L-lactate dehydrogenase B chain

BE0000068ProteinHumansLDHB

Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+). It is acted on by 5 drugs in DrugBank.

Gene name
LDHB
UniProtKB entry
P07195Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
334 residues · 36,638 Da
Also known as
1.1.1.27 · LDH heart subunit · LDH-B · LDH-H · Renal carcinoma antigen NY-REN-46

Resolves to

Protein
UniProtP07195UniProt nameLDHB_HUMAN
Gene
HGNCHGNC:6541NCBI Gene3945GenBank1200083GeneCardsLDHB
Pharmacology
KEGGhsa:3945
Structure
PDB1I0ZPDB1T2FPDB7DBJ
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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30+ReferencesStructured and connected to the statements they support
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Which approved drugs act on L-lactate dehydrogenase B chain, how selective are they, and which programs against it are still in active trials?

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