NADH dehydrogenase [ubiquinone] iron-sulfur protein 5

BE0000089ProteinHumansNDUFS5

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. It is acted on by 1 drug in DrugBank.

Gene name
NDUFS5
UniProtKB entry
O43920Swiss-Prot
Cellular location
Mitochondrion inner membrane
Residues / weight
106 residues · 12,517 Da
Also known as
CI-15 kDa · Complex I-15 kDa · NADH-ubiquinone oxidoreductase 15 kDa subunit

Resolves to

Protein
UniProtO43920UniProt nameNDUS5_HUMAN
Gene
HGNCHGNC:7712NCBI Gene4725GenBank2911482GeneCardsNDUFS5
Pharmacology
KEGGhsa:4725
Structure
PDB5XTCPDB5XTDPDB5XTH
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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11+ReferencesStructured and connected to the statements they support
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Which approved drugs act on NADH dehydrogenase [ubiquinone] iron-sulfur protein 5, how selective are they, and which programs against it are still in active trials?

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