Methylsterol monooxygenase 1

BE0000096ProteinHumansMSMO1

Catalyzes the three-step monooxygenation required for the demethylation of 4,4-dimethyl and 4alpha-methylsterols, which can be subsequently metabolized to cholesterol (PubMed:21285510, PubMed:23583456, PubMed:26114596, PubMed:28673550, PubMed:36958722). It is acted on by 1 drug in DrugBank.

Gene name
MSMO1
UniProtKB entry
Q15800Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
293 residues · 35,215 Da
Also known as
1.14.18.9 · C-4 methylsterol oxidase · DESP4 · ERG25 · SC4MOL

Resolves to

Protein
UniProtQ15800UniProt nameMSMO1_HUMAN
Gene
HGNCHGNC:10545NCBI Gene6307GenBank1408206GeneCardsMSMO1
Pharmacology
KEGGhsa:6307
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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8GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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8+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Methylsterol monooxygenase 1, how selective are they, and which programs against it are still in active trials?

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