Dihydrofolate synthase/folylpolyglutamate synthase

BE0000124ProteinEscherichia coli (strain K12)folC

Functions in two distinct reactions of the de novo folate biosynthetic pathway. It is acted on by 2 drugs in DrugBank.

Gene name
folC
UniProtKB entry
P08192Swiss-Prot
Residues / weight
422 residues · 45,405 Da
Also known as
6.3.2.12 · Bifunctional protein FolC · dedC · DHFS / FPGS · Folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase

Resolves to

Protein
UniProtP08192UniProt nameFOLC_ECOLI
Gene
NCBI Gene945451GenBank146020
Pharmacology
KEGGecj:JW2312
Structure
PDB1W78PDB1W7K
Drugs

What you can answer from here — as of May 03, 2025

2DrugsApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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10+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Dihydrofolate synthase/folylpolyglutamate synthase, and which indications are they being tested in?

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