NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

BE0000137ProteinHumansNDUFV2

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (Probable). It is acted on by 2 drugs in DrugBank.

Gene name
NDUFV2
UniProtKB entry
P19404Swiss-Prot
Cellular location
Mitochondrion inner membrane
Residues / weight
249 residues · 27,391 Da
Also known as
7.1.1.2 · NADH-ubiquinone oxidoreductase 24 kDa subunit · NDUFV2

Resolves to

Protein
UniProtP19404UniProt nameNDUV2_HUMAN
Gene
HGNCHGNC:7717NCBI Gene4729GenBank188852GeneCardsNDUFV2
Pharmacology
KEGGhsa:4729
Structure
PDB5XTBPDB5XTDPDB5XTH
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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9+ReferencesStructured and connected to the statements they support
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Which approved drugs act on NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial, how selective are they, and which programs against it are still in active trials?

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