Penicillin-binding protein 2B

BE0000142ProteinStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)penA

A transpeptidase that forms peptide cross-links between adjacent glycan strands in cell wall peptidoglycan (PG). It is acted on by 2 drugs in DrugBank.

Gene name
penA
UniProtKB entry
P0A3M5Swiss-Prot
Cellular location
Cell membrane
Residues / weight
680 residues · 73,872 Da
Also known as
pbp2b

Resolves to

Protein
UniProtP0A3M5UniProt namePBP2_STRPN
Gene
GenBank14973165
Pharmacology
KEGGspn:SP_1673
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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4+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Penicillin-binding protein 2B, how selective are they, and which programs against it are still in active trials?

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