NAD-dependent malic enzyme, mitochondrial

BE0000148ProteinHumansME2

NAD-dependent mitochondrial malic enzyme that catalyzes the oxidative decarboxylation of malate to pyruvate. It is acted on by 6 drugs in DrugBank.

Gene name
ME2
UniProtKB entry
P23368Swiss-Prot
Cellular location
Mitochondrion matrix
Residues / weight
584 residues · 65,443 Da
Also known as
1.1.1.38 · Malic enzyme 2 · NAD-ME

Resolves to

Protein
UniProtP23368UniProt nameMAOM_HUMAN
Gene
HGNCHGNC:6984NCBI Gene4200GenBank187300GeneCardsME2
Pharmacology
KEGGhsa:4200
Structure
PDB1DO8PDB1EFKPDB1EFL
Drugs

What you can answer from here — as of September 07, 2019

6DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
7GO termsFunction, process and component, as structured annotations
Sign in
2Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
25+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on NAD-dependent malic enzyme, mitochondrial, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In