D-3-phosphoglycerate dehydrogenase

BE0000161ProteinHumansPHGDH

Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. It is acted on by 1 drug in DrugBank.

Gene name
PHGDH
UniProtKB entry
O43175Swiss-Prot
Residues / weight
533 residues · 56,650 Da
Also known as
1.1.1.95 · 2-oxoglutarate reductase · 3-PGDH · Malate dehydrogenase · PGDH3

Resolves to

Protein
UniProtO43175UniProt nameSERA_HUMAN
Gene
HGNCHGNC:8923NCBI Gene26227GenBank2674062GeneCardsPHGDH
Pharmacology
KEGGhsa:26227
Structure
PDB2G76PDB5N53PDB5N6C
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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17+ReferencesStructured and connected to the statements they support
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Which approved drugs act on D-3-phosphoglycerate dehydrogenase, how selective are they, and which programs against it are still in active trials?

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