DNA ligase 3

BE0000167ProteinHumansLIG3

Isoform 3 functions as a heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. It is acted on by 1 drug in DrugBank.

Gene name
LIG3
UniProtKB entry
P49916Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
1,009 residues · 112,906 Da
Also known as
6.5.1.1 · DNA ligase III · Polydeoxyribonucleotide synthase [ATP] 3

Resolves to

Protein
UniProtP49916UniProt nameDNLI3_HUMAN
Gene
HGNCHGNC:6600NCBI Gene3980GenBank860963GeneCardsLIG3
Pharmacology
KEGGhsa:3980
Structure
PDB10YEPDB10YFPDB10YG
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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18GO termsFunction, process and component, as structured annotations
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5Pfam domainsDomain architecture mapped to Pfam families and clans
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21+ReferencesStructured and connected to the statements they support
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Which approved drugs act on DNA ligase 3, how selective are they, and which programs against it are still in active trials?

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