Cytochrome c oxidase subunit FA4

BE0000169ProteinHumansCOXFA4

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. It is acted on by 1 drug in DrugBank.

Gene name
COXFA4
UniProtKB entry
O00483Swiss-Prot
Cellular location
Mitochondrion inner membrane
Residues / weight
81 residues · 9,370 Da
Also known as
CI-MLRQ · Complex I-MLRQ · Cytochrome c oxidase subunit NDUFA4 · NADH-ubiquinone oxidoreductase MLRQ subunit · NDUFA4

Resolves to

Protein
UniProtO00483UniProt nameCXFA4_HUMAN
Gene
HGNCHGNC:7687NCBI Gene4697GenBank1946692GeneCardsCOXFA4
Pharmacology
KEGGhsa:4697
Structure
PDB5Z62PDB9I7U
Drugs

What you can answer from here — as of June 05, 2026

1DrugApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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11+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Cytochrome c oxidase subunit FA4, how selective are they, and which programs against it are still in active trials?

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