NADH dehydrogenase [ubiquinone] 1 subunit C2

BE0000173ProteinHumansNDUFC2

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis but required for the complex assembly. It is acted on by 2 drugs in DrugBank.

Gene name
NDUFC2
UniProtKB entry
O95298Swiss-Prot
Cellular location
Mitochondrion inner membrane
Residues / weight
119 residues · 14,187 Da
Also known as
CI-B14.5b · Complex I-B14.5b · HLC-1 · Human lung cancer oncogene 1 protein · NADH-ubiquinone oxidoreductase subunit B14.5b

Resolves to

Protein
UniProtO95298UniProt nameNDUC2_HUMAN
Gene
HGNCHGNC:7706NCBI Gene4718GenBank4191346GeneCardsNDUFC2
Pharmacology
KEGGhsa:4718
Structure
PDB5XTCPDB5XTDPDB5XTH
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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11GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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14+ReferencesStructured and connected to the statements they support
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Which approved drugs act on NADH dehydrogenase [ubiquinone] 1 subunit C2, how selective are they, and which programs against it are still in active trials?

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