B-cell receptor CD22

BE0000183ProteinHumansCD22

Most highly expressed siglec (sialic acid-binding immunoglobulin-like lectin) on B-cells that plays a role in various aspects of B-cell biology including differentiation, antigen presentation, and trafficking to bone marrow (PubMed:34330755, PubMed:8627166). It is acted on by 12 drugs in DrugBank.

Gene name
CD22
UniProtKB entry
P20273Swiss-Prot
Cellular location
Cell membrane
Residues / weight
847 residues · 95,347 Da
Also known as
B-lymphocyte cell adhesion molecule · BL-CAM · Sialic acid-binding Ig-like lectin 2 · Siglec-2 · SIGLEC2

Resolves to

Protein
UniProtP20273UniProt nameCD22_HUMAN
Gene
HGNCHGNC:1643NCBI Gene933GenBank36091GeneCardsCD22
Pharmacology
IUPHAR/GtoPdb2786KEGGhsa:933
Structure
PDB5VKJPDB5VKMPDB5VL3
Drugs

What you can answer from here — as of September 07, 2019

12DrugsApproved to experimental, with action, bond type and pharmacological action
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31Clinical trialsTrials of drugs acting on it, by phase and status
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3GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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43+ReferencesStructured and connected to the statements they support
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Which approved drugs act on B-cell receptor CD22, how selective are they, and which programs against it are still in active trials?

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