3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7

BE0000184ProteinHumansHSD17B7

Bifunctional enzyme involved in steroid-hormone metabolism and cholesterol biosynthesis (PubMed:11165030, PubMed:12574203, PubMed:12732193, PubMed:12829805, PubMed:19772289, PubMed:20659585). It is acted on by 1 drug in DrugBank.

Gene name
HSD17B7
UniProtKB entry
P56937Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
341 residues · 38,206 Da
Also known as
17-beta-HSD 7 · 17-beta-hydroxysteroid dehydrogenase 7 · 17HSD7 · 3-keto-steroid reductase · Dihydrotestosterone oxidoreductase

Resolves to

Protein
UniProtP56937UniProt nameDHB7_HUMAN
Gene
HGNCHGNC:5215NCBI Gene51478GenBank6721095GeneCardsHSD17B7
Pharmacology
KEGGhsa:51478
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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11+ReferencesStructured and connected to the statements they support
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Which approved drugs act on 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7, how selective are they, and which programs against it are still in active trials?

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