Glutathione synthetase

BE0000185ProteinHumansGSS

Catalyzes the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner (PubMed:7646467, PubMed:9215686). It is acted on by 7 drugs in DrugBank.

Gene name
GSS
UniProtKB entry
P48637Swiss-Prot
Residues / weight
474 residues · 52,384 Da
Also known as
6.3.2.3 · Glutathione synthase · GSH synthetase · GSH-S

Resolves to

Protein
UniProtP48637UniProt nameGSHB_HUMAN
Gene
HGNCHGNC:4624NCBI Gene2937GenBank886284GeneCardsGSS
Pharmacology
KEGGhsa:2937
Structure
PDB2HGSPDB8FBZ
Drugs

What you can answer from here — as of September 07, 2019

7DrugsApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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27+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Glutathione synthetase, how selective are they, and which programs against it are still in active trials?

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