NADH-ubiquinone oxidoreductase chain 3

BE0000196ProteinHumansMT-ND3

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:25118196). It is acted on by 2 drugs in DrugBank.

Gene name
MT-ND3
UniProtKB entry
P03897Swiss-Prot
Cellular location
Mitochondrion inner membrane
Residues / weight
115 residues · 13,186 Da
Also known as
7.1.1.2 · MTND3 · NADH dehydrogenase subunit 3 · NADH3 · ND3

Resolves to

Protein
UniProtP03897UniProt nameNU3M_HUMAN
Gene
HGNCHGNC:7458NCBI Gene4537GenBank506832GeneCardsMT-ND3
Pharmacology
KEGGhsa:4537
Structure
PDB5XTCPDB5XTDPDB9CWT
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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17+ReferencesStructured and connected to the statements they support
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Which approved drugs act on NADH-ubiquinone oxidoreductase chain 3, how selective are they, and which programs against it are still in active trials?

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