Lysine--tRNA ligase

BE0000198ProteinHumansKARS1

Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor... It is acted on by 1 drug in DrugBank.

Gene name
KARS1
UniProtKB entry
Q15046Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
597 residues · 68,048 Da
Also known as
2.7.7.- · 6.1.1.6 · KARS · KIAA0070 · LysRS

Resolves to

Protein
UniProtQ15046UniProt nameSYK_HUMAN
Gene
HGNCHGNC:6215NCBI Gene3735GenBank505108GeneCardsKARS1
Pharmacology
KEGGhsa:3735
Structure
PDB3BJUPDB4DPGPDB4YCU
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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14GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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26+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Lysine--tRNA ligase, how selective are they, and which programs against it are still in active trials?

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