NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6

BE0000213ProteinHumansNDUFA6

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. It is acted on by 1 drug in DrugBank.

Gene name
NDUFA6
UniProtKB entry
P56556Swiss-Prot
Cellular location
Mitochondrion inner membrane
Residues / weight
128 residues · 15,136 Da
Also known as
CI-B14 · Complex I-B14 · LYR motif-containing protein 6 · LYRM6 · NADH-ubiquinone oxidoreductase B14 subunit

Resolves to

Protein
UniProtP56556UniProt nameNDUA6_HUMAN
Gene
HGNCHGNC:7690NCBI Gene4700GenBank2909856GeneCardsNDUFA6
Pharmacology
KEGGhsa:4700
Structure
PDB5XTBPDB5XTDPDB5XTH
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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10+ReferencesStructured and connected to the statements they support
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Which approved drugs act on NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6, how selective are they, and which programs against it are still in active trials?

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