Tryptophan--tRNA ligase, cytoplasmic

BE0000228ProteinHumansWARS1

Catalyzes the attachment of tryptophan to tRNA(Trp) in a two-step reaction: tryptophan is first activated by ATP to form Trp-AMP and then transferred to the acceptor end of the tRNA(Trp). It is acted on by 3 drugs in DrugBank.

Gene name
WARS1
UniProtKB entry
P23381Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
471 residues · 53,165 Da
Also known as
6.1.1.2 · hWRS · IFI53 · IFP53 · Interferon-induced protein 53

Resolves to

Protein
UniProtP23381UniProt nameSYWC_HUMAN
Gene
HGNCHGNC:12729NCBI Gene7453GenBank184657GeneCardsWARS1
Pharmacology
KEGGhsa:7453
Structure
PDB1O5TPDB1R6TPDB1R6U
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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39+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Tryptophan--tRNA ligase, cytoplasmic, how selective are they, and which programs against it are still in active trials?

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