Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial

BE0000231ProteinHumansALDH6A1

Malonate and methylmalonate semialdehyde dehydrogenase involved in the catabolism of valine, thymine, and compounds catabolized by way of beta-alanine, including uracil and cytidine. It is acted on by 1 drug in DrugBank.

Gene name
ALDH6A1
UniProtKB entry
Q02252Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
535 residues · 57,839 Da
Also known as
1.2.1.27 · Aldehyde dehydrogenase family 6 member A1 · Malonate-semialdehyde dehydrogenase [acylating] · MMSDH

Resolves to

Protein
UniProtQ02252UniProt nameMMSA_HUMAN
Gene
HGNCHGNC:7179NCBI Gene4329GenBank7160985GeneCardsALDH6A1
Pharmacology
KEGGhsa:4329
Structure
PDB8XXQPDB9IZUPDB9IZV
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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9+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial, how selective are they, and which programs against it are still in active trials?

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