Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

BE0000235ProteinHumansSLC25A12

Mitochondrial electrogenic aspartate/glutamate antiporter that favors efflux of aspartate and entry of glutamate and proton within the mitochondria as part of the malate-aspartate shuttle (PubMed:11566871, PubMed:19641205, PubMed:24515575, PubMed:38945283). It is acted on by 1 drug in DrugBank.

Gene name
SLC25A12
UniProtKB entry
O75746Swiss-Prot
Cellular location
Mitochondrion inner membrane
Residues / weight
678 residues · 74,761 Da
Also known as
AGC1 · Araceli hiperlarga · Aralar · ARALAR1 · Mitochondrial aspartate glutamate carrier 1

Resolves to

Protein
UniProtO75746UniProt nameS2512_HUMAN
Gene
HGNCHGNC:10982NCBI Gene8604GenBank3559910GeneCardsSLC25A12
Pharmacology
KEGGhsa:8604
Structure
PDB4P5XPDB4P60
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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15+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial, how selective are they, and which programs against it are still in active trials?

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