Trifunctional enzyme subunit alpha, mitochondrial

BE0000260ProteinHumansHADHA

Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway (PubMed:1550553, PubMed:29915090, PubMed:30850536, PubMed:8135828, PubMed:31604922). It is acted on by 2 drugs in DrugBank.

Gene name
HADHA
UniProtKB entry
P40939Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
763 residues · 82,999 Da
Also known as
78 kDa gastrin-binding protein · HADH · MLCL AT · Monolysocardiolipin acyltransferase · TP-alpha

Resolves to

Protein
UniProtP40939UniProt nameECHA_HUMAN
Gene
HGNCHGNC:4801NCBI Gene3030GenBank862457GeneCardsHADHA
Pharmacology
KEGGhsa:3030
Structure
PDB5ZQZPDB5ZRVPDB6DV2
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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9GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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20+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Trifunctional enzyme subunit alpha, mitochondrial, how selective are they, and which programs against it are still in active trials?

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