Kynurenine--oxoglutarate transaminase 1

BE0000273ProteinHumansKYAT1

Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA), an intermediate in the tryptophan catabolic pathway which is also a broad spectrum antagonist of the three ionotropic excitatory amino acid... It is acted on by 8 drugs in DrugBank.

Gene name
KYAT1
UniProtKB entry
Q16773Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
422 residues · 47,875 Da
Also known as
2.6.1.7 · CCBL1 · Cysteine-S-conjugate beta-lyase · Glutamine transaminase K · Glutamine--phenylpyruvate transaminase

Resolves to

Protein
UniProtQ16773UniProt nameKAT1_HUMAN
Gene
HGNCHGNC:1564NCBI Gene883GenBank758591GeneCardsKYAT1
Pharmacology
KEGGhsa:883
Structure
PDB1W7LPDB1W7MPDB1W7N
Drugs

What you can answer from here — as of September 07, 2019

8DrugsApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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20+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Kynurenine--oxoglutarate transaminase 1, how selective are they, and which programs against it are still in active trials?

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