T-cell surface glycoprotein CD3 epsilon chain

BE0000274ProteinHumansCD3E

Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response (PubMed:15294938, PubMed:15546002, PubMed:2470098, PubMed:40592325, PubMed:8490660). It is acted on by 18 drugs in DrugBank.

Gene name
CD3E
UniProtKB entry
P07766Swiss-Prot
Cellular location
Cell membrane
Residues / weight
207 residues · 23,147 Da
Also known as
T-cell surface antigen T3/Leu-4 epsilon chain · T3E

Resolves to

Protein
UniProtP07766UniProt nameCD3E_HUMAN
Gene
HGNCHGNC:1674NCBI Gene916GenBank469945GeneCardsCD3E
Pharmacology
IUPHAR/GtoPdb2742KEGGhsa:916
Structure
PDB1A81PDB1SY6PDB1XIW
Drugs

What you can answer from here — as of September 07, 2019

18DrugsApproved to experimental, with action, bond type and pharmacological action
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18GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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44+ReferencesStructured and connected to the statements they support
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Which approved drugs act on T-cell surface glycoprotein CD3 epsilon chain, how selective are they, and which programs against it are still in active trials?

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