Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial

BE0000277ProteinHumansSLC25A13

Mitochondrial electrogenic aspartate/glutamate antiporter that favors efflux of aspartate and entry of glutamate and proton within the mitochondria as part of the malate-aspartate shuttle (PubMed:11566871, PubMed:38937634, PubMed:38945283, PubMed:39419476). It is acted on by 1 drug in DrugBank.

Gene name
SLC25A13
UniProtKB entry
Q9UJS0Swiss-Prot
Cellular location
Mitochondrion inner membrane
Residues / weight
675 residues · 74,175 Da
Also known as
AGC2 · ARALAR-related gene 2 · ARALAR2 · Calcium-binding mitochondrial carrier protein Aralar2 · Citrin

Resolves to

Protein
UniProtQ9UJS0UniProt nameS2513_HUMAN
Gene
HGNCHGNC:10983NCBI Gene10165GenBank22002963GeneCardsSLC25A13
Pharmacology
KEGGhsa:10165
Structure
PDB4P5W
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
Sign in
6GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
16+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In