NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3

BE0000284ProteinHumansNDUFB3

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. It is acted on by 1 drug in DrugBank.

Gene name
NDUFB3
UniProtKB entry
O43676Swiss-Prot
Cellular location
Mitochondrion inner membrane
Residues / weight
98 residues · 11,402 Da
Also known as
CI-B12 · Complex I-B12 · NADH-ubiquinone oxidoreductase B12 subunit

Resolves to

Protein
UniProtO43676UniProt nameNDUB3_HUMAN
Gene
HGNCHGNC:7698NCBI Gene4709GenBank2909858GeneCardsNDUFB3
Pharmacology
KEGGhsa:4709
Structure
PDB5XTCPDB5XTDPDB5XTH
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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9+ReferencesStructured and connected to the statements they support
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Which approved drugs act on NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3, how selective are they, and which programs against it are still in active trials?

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