Sodium-coupled neutral amino acid transporter 3

BE0000285ProteinHumansSLC38A3

Symporter that cotransports specific neutral amino acids and sodium ions, coupled to an H(+) antiporter activity (PubMed:10823827). It is acted on by 3 drugs in DrugBank.

Gene name
SLC38A3
UniProtKB entry
Q99624Swiss-Prot
Cellular location
Cell membrane
Residues / weight
504 residues · 55,772 Da
Also known as
G17 · N-system amino acid transporter 1 · Na(+)-coupled neutral amino acid transporter 3 · NAT1 · SN1

Resolves to

Protein
UniProtQ99624UniProt nameS38A3_HUMAN
Gene
HGNCHGNC:18044NCBI Gene10991GenBank10242111GeneCardsSLC38A3
Pharmacology
KEGGhsa:10991
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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18GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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13+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Sodium-coupled neutral amino acid transporter 3, how selective are they, and which programs against it are still in active trials?

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