NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial

BE0000313ProteinHumansNDUFC1

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. It is acted on by 1 drug in DrugBank.

Gene name
NDUFC1
UniProtKB entry
O43677Swiss-Prot
Cellular location
Mitochondrion inner membrane
Residues / weight
76 residues · 8,734 Da
Also known as
CI-KFYI · Complex I-KFYI · NADH-ubiquinone oxidoreductase KFYI subunit

Resolves to

Protein
UniProtO43677UniProt nameNDUC1_HUMAN
Gene
HGNCHGNC:7705NCBI Gene4717GenBank2909860GeneCardsNDUFC1
Pharmacology
KEGGhsa:4717
Structure
PDB5XTCPDB5XTDPDB5XTH
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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6+ReferencesStructured and connected to the statements they support
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Which approved drugs act on NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial, how selective are they, and which programs against it are still in active trials?

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