3-hydroxyacyl-CoA dehydrogenase type-2

BE0000317ProteinHumansHSD17B10

Mitochondrial dehydrogenase involved in pathways of fatty acid, branched-chain amino acid and steroid metabolism (PubMed:10600649, PubMed:12917011, PubMed:18996107, PubMed:19706438, PubMed:20077426, PubMed:25925575, PubMed:26950678, PubMed:28888424, PubMed:9553139). It is acted on by 5 drugs in DrugBank.

Gene name
HSD17B10
UniProtKB entry
Q99714Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
261 residues · 26,923 Da
Also known as
1.1.1.35 · 17-beta-estradiol 17-dehydrogenase · 2-methyl-3-hydroxybutyryl-CoA dehydrogenase · 3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+)) · 3-hydroxy-2-methylbutyryl-CoA dehydrogenase

Resolves to

Protein
UniProtQ99714UniProt nameHCD2_HUMAN
Gene
HGNCHGNC:4800NCBI Gene3028GenBank2558754GeneCardsHSD17B10
Pharmacology
KEGGhsa:3028
Structure
PDB1SO8PDB1U7TPDB2O23
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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10GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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24+ReferencesStructured and connected to the statements they support
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Which approved drugs act on 3-hydroxyacyl-CoA dehydrogenase type-2, how selective are they, and which programs against it are still in active trials?

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