NADP-dependent malic enzyme, mitochondrial

BE0000328ProteinHumansME3

Catalyzes the oxidative decarboxylation of (S)-malate to pyruvate using NADP(+), and is able to reverse the reaction but only with significantly lower efficiency (PubMed:7818469). It is acted on by 2 drugs in DrugBank.

Gene name
ME3
UniProtKB entry
Q16798Swiss-Prot
Cellular location
Mitochondrion matrix
Residues / weight
604 residues · 67,068 Da
Also known as
1.1.1.40 · Malic enzyme 3 · NADP-ME

Resolves to

Protein
UniProtQ16798UniProt nameMAON_HUMAN
Gene
HGNCHGNC:6985NCBI Gene10873GenBank535012GeneCardsME3
Pharmacology
KEGGhsa:10873
Structure
PDB8E76PDB8E78PDB8E8O
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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2GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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8+ReferencesStructured and connected to the statements they support
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Which approved drugs act on NADP-dependent malic enzyme, mitochondrial, how selective are they, and which programs against it are still in active trials?

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