Acetyl-coenzyme A synthetase, cytoplasmic

BE0000350ProteinHumansACSS2

Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids (PubMed:10843999, PubMed:28003429, PubMed:28552616, PubMed:38369012, PubMed:39561764). It is acted on by 4 drugs in DrugBank.

Gene name
ACSS2
UniProtKB entry
Q9NR19Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
701 residues · 78,579 Da
Also known as
6.2.1.1 · ACAS2 · AceCS · AceCS1 · Acetate--CoA ligase

Resolves to

Protein
UniProtQ9NR19UniProt nameACSA_HUMAN
Gene
HGNCHGNC:15814NCBI Gene55902GenBank8439651GeneCardsACSS2
Pharmacology
IUPHAR/GtoPdb3128KEGGhsa:55902
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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20+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Acetyl-coenzyme A synthetase, cytoplasmic, how selective are they, and which programs against it are still in active trials?

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