NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8

BE0000367ProteinHumansNDUFA8

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis (PubMed:27626371, PubMed:32385911, PubMed:33153867). It is acted on by 1 drug in DrugBank.

Gene name
NDUFA8
UniProtKB entry
P51970Swiss-Prot
Cellular location
Mitochondrion inner membrane
Residues / weight
172 residues · 20,105 Da
Also known as
CI-19kD · CI-PGIV · Complex I-19kD · Complex I-PGIV · NADH-ubiquinone oxidoreductase 19 kDa subunit

Resolves to

Protein
UniProtP51970UniProt nameNDUA8_HUMAN
Gene
HGNCHGNC:7692NCBI Gene4702GenBank5326825GeneCardsNDUFA8
Pharmacology
KEGGhsa:4702
Structure
PDB5XTCPDB5XTDPDB5XTH
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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12+ReferencesStructured and connected to the statements they support
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Which approved drugs act on NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8, how selective are they, and which programs against it are still in active trials?

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