Ornithine decarboxylase antizyme 1

BE0000371ProteinHumansOAZ1

Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. It is acted on by 1 drug in DrugBank.

Gene name
OAZ1
UniProtKB entry
P54368Swiss-Prot
Residues / weight
228 residues · 25,405 Da
Also known as
AZ1 · OAZ · ODC-Az

Resolves to

Protein
UniProtP54368UniProt nameOAZ1_HUMAN
Gene
HGNCHGNC:8095NCBI Gene4946GenBank852429GeneCardsOAZ1
Pharmacology
KEGGhsa:4946
Structure
PDB4ZGYPDB4ZGZPDB5BWA
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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2GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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9+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Ornithine decarboxylase antizyme 1, how selective are they, and which programs against it are still in active trials?

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